Informatics Publishing Limited

B. Venkata Phani Deepthi ¹, D. Varun ¹, P. N. V. Gopal ¹, CH. Babu Rao ², G. Sumalatha ¹

Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh, IN
2 Don Bosco PG College of Pharmacy, Pulladigunta, Guntur Dt, Andhra Pradesh, IN

Abstract

Gastro retentive drug delivery system is developed mainly for those drugs that are having narrow therapeutic window and are absorbed mainly in the stomach. A number of controlled drug delivery systems are available to increase the gastric residence time of the drug namely muco adhesive /bio adhesive systems, high density ,magnetic systems, super porous hydrogels, raft systems, low density systems, floating ion exchange resins. Among these super porous hydrogels are one of the most promising drug delivery systems as they swell very fastly upto 200 times of their own weight. These swollen hydrogels remains in the stomach for prolonged periods and releases the loaded drugs. This unique swelling property allows them to be used as a gastric retention carriers provides sustained release. The present review mainly focuses on formulation ,preparation and characterization and applications of super porous hydrogels.

Keywords

Super Porous Hydrogels (SPHs), Swelling, Monomers, Acrylates etc.

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P. Nagaraju ¹, B. Sridhar ², P. Jitendra Kumar ³, U. Upendra Rao ¹, K. Hanumantha Rao ², P. N. V. Gopal ¹

Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh, IN
2 DCRM Pharmacy College, Inkollu, Andhra Pradesh, IN
3 Siddhartha Institute of Pharmacy, Sattenapalli, Andhra Pradesh, IN

Abstract

The present work describes a simple reverse phase HPLC method for the estimation of Atorvastatin calcium in bulk and pharmaceutical formulations. The estimation was carried out on phenomenex C₁₈ (250 × 4.6 mm, 5μ) column using a mobile phase containing of Acetonitrile: Ortho-phosphoric acid (0.1%): Tetrahydrofuran (48:0.04:52). The eluent was monitored at 244 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Keywords

HPLC, Validation, Atorvastatin Calcium and Pharmaceutical Formulation.

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P. Nagaraju ¹, V. D. N. Srinivas ¹, S. V. N. Padma ¹, P. N. V. Gopal ¹, D. Mallikarjuna Rao ¹

Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur, IN

Abstract

Over the past decade, cavity ring down spectroscopy has emerged as a powerful technique for performing direct absorption measurements using pulsed lasers. Cavity ring down spectroscopy has since been used from the ultraviolet to the mid-infrared. It is a direct absorption technique, which can be performed with pulsed or continuous light sources and has a significantly higher sensitivity than obtainable in conventional absorption spectroscopy. It can be used to measure the concentration of some light-absorbing substances. Typically, the substances to be measured are in gaseous form. This technique is most widely known as cavity ring-down spectroscopy, although the alternative, but more cumbersome, cavity ring-down laser absorption spectroscopy is preferred by some authors. Here we discuss about the experimental implementation of Cavity ring down spectroscopy and its application to a number of areas of research including laser diagnostics of hostile environments, reaction kinetics and spectroscopy, with particular emphasis on our ongoing studies of the fast (sub-nanosecond) pre dissociation of electronically excited states of small molecules and radicals.

Keywords

Cavity Ring Down Spectroscopy, Absorption Spectroscopy.

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